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In experimental systems, DSIP has been explored for its potential ability to influence the stability and duration of these delta-dominant sleep cycles

The interpretation has been debated

These have a place, but their effect is constrained by one fundamental problem: most peptides dont cross the skin barrier in meaningful amounts

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Several rAAV vectors efficiently cross the blood-brain barrier and transduce neurons and astrocytes in the neonatal mouse central nervous system

Broad gene-mapping work led by Pickart and colleagues reported modulation of thousands of genes, with roughly a third of human gene patterns shifting toward expression states associated with younger or healthier tissue