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Human trials are needed to confirm its safety and effectiveness before widespread clinical use

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Vewinger N, Huprich S, Seidmann L, Russo A, Alt F, Bender H, et al

Future studies should initially focus on observational cohorts studies to evaluate whether lower circulating levels of factors such as IGF1 or VEGF correlated with accelerated clinical progression or greater symptoms severity in PD patients

Safety and interactions of proton pump inhibitors: lessons learned in millions of patients