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This process is exacerbated by the formation of neutrophil extracellular traps (NETs), web-like structures composed of DNA, NE, and other antimicrobial factors

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Deferoxamine, the first FDA-approved drug in 1968 (Parker et al., 2023), is administered via intravenous (IV) or intramuscular (IM) injection due to its poor oral bioavailability, which is one of the most significant limitations of the DFO treatment (Entezari et al., 2022)

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These findings suggest that patients with liver disease have an impaired ability to metabolize protein nitrogen and to synthesize urea

PMID: 34942583