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One hundred and forty-one treatment-nave patients were classified into hepatitis B e antigen-negative chronic infection (HBeAg - CInf, n=44), HBeAg-negative chronic hepatitis (HBeAg - CHep, n=20), HBeAg + CInf (n=36), and HBeAg + CHep (n=41) based on an issued clinical practice guideline (19, 20)

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A 96-well plate was coated with 4 g/mL of rat anti-mouse lipocalin-2 capture antibody and incubated overnight at room temperature