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Calpain-independent intracellular protease activity is elevated in excitotoxic cortical neurons prior to delayed calcium deregulation and mitochondrial dysfunction

Thermogenic activation induces FGF21 expression and release in brown adipose tissue

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Free SH groups as in reduced GSH, are essential for the activity of all metabolite carriers in the inner mitochondrial membrane, otherwise, extensive thiol oxidation results in: the inhibition of transport activity, and the dissipation of the mitochondrial inner transmembrane potential ( [ ]), an early, potentially reversible event observed in mitochondrial related apoptotic processes, bioenergetic failure, also an early event that is part of the dissipation of [ ], and an increase in the permeability of the mitochondrial membrane, a later event in mitochondrial related apoptotic processes

The only non-neutralized ROS generated by intact RBCs involves the small fraction of Hb that binds to the RBC membrane

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