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Deferoxamine reduces endothelial ferroptosis and protects cerebrovascular function after experimental traumatic brain injury

Ferroptosis inducers and stroke In animal models of ischemic stroke and associated clinical specimens, it was found that, when cerebral ischemia-reperfusion occurs, an increase in the level of iron ions exacerbates neuronal damage (111)

Conversely, reducing KYNA through targeted KAT deletion enhances hippocampal glutamatergic tone, improving cognitive performance and synaptic plasticity [30]

10.1016/j.freeradbiomed.2015.09.022 Free Radic

14 BlaessM.KaiserL.SauerM.CsukR.DeignerH

Furthermore, these results are consistent with previous 1 H-MRS studies in humans that found IV ketamine elevates ACC glutamine and Glx immediately 9,10 and ACC glutamate levels after 35 min in healthy individuals 8 , together with studies in patients with MDD that reported an acute mPFC Glx increase 11 and an increase prefrontal 13 C-glutamine 13 following IV ketamine administration