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3.2 Effects of Piezo1 under abnormal conditions Under normal conditions, Piezo1 expression plays an integral role in signaling in the central nervous system

Blood (2015) 2203:abstract 2203

TGF-1-induced tubular lipid peroxidation (linked to renal failure) is reversed by GPX4 (206), while GPX4 deficiency exacerbates TGF-1 production and fibrosiseffects reversed by GPX4 upregulation (207)