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Despite RIC is classified as an autosomal recessive disorder, five of the seven Japanese patients with RIC in a retrospective study were compound heterozygous, and two were simple heterozygous with a single variant of the ATP8B1 or ABCB11 genes

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However, these approaches are often limited by issues such as drug resistance, rapid metabolism, and significant side effects [9, 10]

The cost of that breadth is that it leans on mechanism and individual trials rather than a single combination headline

DL-Threo- -benzyloxyaspartate (TBOA) is a glutamate uptake blocker frequently used to induce excitotoxicity

Smith MB, Haney E, McDonagh M, Pappas M, Daeges M, Wasson N, et al