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In fibromyalgia, oxidative stress has also been linked to pathophysiology (Cordero et al., 2010) with studies suggesting that antioxidant therapies may help reduce elevated pro-oxidative pathways such as lipid peroxidation and mitophagy (Assavarittirong et al., 2017) with melatonin being shown to improve brain function in the GWS model, through modulation of oxidative stress (Madhu et al., 2021)

doi: 10.1186/1476-511X-13-75 247 CainSAMonkPN

2024 Apr 14];5(1):97

Moreover, MO25 plays a key role in stabilizing the LKB1 activation loop in a conformation required for phosphorylation of substrates [79]

if lipid free radicals (PL) meet O 2 , they will combine with them to form peroxide free radicals (PL-OO), and these peroxide free radicals will extract hydrogen from neighboring polyunsaturated fatty acids (PUFAs) to produce lipids hydroperoxides (PL-OOH) (Conrad and Pratt, 2019)

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