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[DOI] [PubMed] [Google Scholar] 96.Pou S., Pou W., Bredt D., Snyder S., Rosen G

Mitochondrial crisis in cerebrovascular endothelial cells opens the bloodbrain barrier

See text for argumentation of FRDA and FECH interactions during heme biosynthesis

Foundational syntheses, such as that reported by Schneede et al (3), have established the enzymatic basis of HCU, emphasized homocysteine as a pathogenic vascular risk factor and summarized the then-standard treatments: i) Dietary methionine restriction

Annu Rev Pharmacol Toxicol 57:309327

(2021) found pathological iron deposition in the hippocampus and substantia nigra of AD patients, which was highly correlated with the progression of the disease