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Serine is precursor of many important cellular compounds, including purines, pyrimidines, sphingolipids, folate, and of the amino acids glycine, cysteine, and tryptophan

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Because they have a limited blood supply, their healing process is slower compared to muscles or skin

It is therefore assumed that transcription from gdhA P2 serves to enhance gdhA expression when the concentration of -ketoglutarate is low, as during invasive disease, both to enhance the activity of the TCA cycle in the catabolic reaction, and to provide L-glutamate for glutathione biosynthesis in the anabolic reaction

doi: 10.1016/j.jclepro.2014.05.069 75

Head Neck 46(8):1881-1892, 2024