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Variability between genetically distinct populations Certain cell surface proteins exhibit a genetically determined high degree of inter-donor variability in expression, including CR1 and complement molecules C4A and C4B 31,32

Using an in vitro PHGDH enzyme assay, they determined CBR-5884 to be a weak and selective PHGDH inhibitor (IC 50 = 33 12 mM), whose mode of action involves the disruption of the enzymes tetrameric state in favour of the dimeric conformation 20

This increased ATP consumption in astrocytes leads to greater glucose uptake, mediated by an increase in glucose transporter production, which in turn boosts glycolysis and lactate production via LDHA

J Alzheimers Dis 6(4):367377 Bayir H (2005) Reactive oxygen species

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