l-carnitine and digestive enzymes for weight loss Beneficial effects of supplementation management in overweight obese adults: An updated systematic review and dose-response meta-analysis of randomized controlled trials Canprev Digestive Enzymes - 90

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A full validation of the methods was performed according to the current guidelines

Continuous data with a normal distribution [age, BMI, insomnia duration, GAD-7 score, PHQ-9 score, PSQI score, IGF-1 score, total sleep time, sleep latency, sleep efficiency, rapid eye movement (REM) sleep, stage 1 non-REM (stage N1), stage 2 non-REM (stage N2), stage 3 non-REM (stage N3), stage N1 time, stage N2 time, stage N3 time, REM sleep latency, REM arousal index, arousal index, apnea-hypopnea index (AHI), periodic limb movement index (PLMI), mean SaO 2 , minimum SaO 2 , and end-tidal CO 2 ] were expressed as means and standard deviations and compared among groups by using one-way ANOVA

Weight-based dosing considerations While the standard clinical trial protocols use fixed-dose titration schedules regardless of body weight, some researchers adjust their approach based on body composition

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Liu (EPFL) for their helpful comments on the manuscript