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injection of ergometrine (3 mg/kg bw) (Slaytor and Wright 1962)

ZarkovicNZarkovicKMilkovicLAndrisicLBorovicSWaegGet alRevealing 4-Hydroxynonenal-Histidine adducts as qualitative and quantitative biomarker of oxidative stress, lipid peroxidation and oxidative homeostasis

In the transition metal chelation mechanism, polyphenol anions chelate heavy metals through the deprotonation of hydroxyl groups, forming metal complexes and releasing a proton (ArOH ArO + H+) (160)

Note that patients treated with IFN- also show a strong decrease in the serum TKR ratio (214)

The cystine transporter SLC7A11 critically restores/maintains intracellular GSH

Natural Compounds That Modulate Nrf2 Pathways There has been a wealth of research looking at agents (naturally occurring and synthetic) that can upregulate this global antioxidant and detoxification system