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GPX4 and GSH, as important intracellular antioxidants, protect cells from ferroptosis

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Epigenetic changes, telomere shortening and DNA damage, proteotoxicity, mitochondrial dysfunction, and changes in intercellular communication and key signaling pathways (MAPK, 176 JAK-STAT3, 177 and Notch 178 ) all lead to permanent cell cycle arrest and exhaustion of satellite cell pools

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As an antioxidant, glutathione may help to reduce oxidative stress and inflammation, which are factors that can contribute to hormonal imbalances, including excess estrogen levels