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Metformin has garnered interest as a potential agent for anti-aging and weight management , but it is not FDA-approved for these purposes

Consequently, current ferroptosis inhibitors risk off-target toxicities and narrow therapeutic indices

Martinez ME, Charalambous M, Saferali A, Fiering S, Naumova AK, St Germain D et al

Furthermore, physiologic levels of Gln reduces the expression of adhesion molecules and migration of leukocytes in ECs activated by preeclamptic plasma or arsenic [59,60]

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For instance, it should be considered that the activity of the mesial temporal cortex, involved in the control of memory and food intake in the central nervous system (CNS), is functionally impaired in dementia