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DiekmannFChouvarinePSallmonHMeyer-KobbeLKieslichMPlouffeBDet al

CVDs remain the leading cause of death globally, despite the availability of numerous clinical treatments for CVDs

( TNF- is mainly produced by activated macrophages, NK cells and T lymphocytes

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Overexpression of CAT in the heart has been shown to effectively reduce intracellular ROS levels, improve mitochondrial structural abnormalities, and contribute to the maintenance of normal cardiac function [128]

The thioredoxin system further contributes to cellular redox buffering, particularly in neurons where copper dysregulation can induce oxidative injury (45)