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Importantly, no significant impact on food intake and no observable adverse effects were reported, suggesting a metabolic rather than appetite-mediated mechanism of action

It is their mechanism of action

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The methods used to collect variables in the research data have been validated to minimize bias and the data in the final analysis has been thoroughly adjusted

But given that these side effects are very rare, taking vitamin B12 at bedtime should be fine unless sleep disruption becomes a persistent symptom after taking supplements

Older adults, those with certain digestive conditions, and people who take some common medications may get very little from an oral pill, no matter how high the dose