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The first and perhaps most straightforward of these mechanisms is increased mass-specific body oxygen stores which delay the onset of hypoxemia and tissue hypoxia and prolong submergence times (Ponganis et al., 1993

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In a PD animal model, tenuigenin significantly improved motor behavior and reduced dopaminergic neuronal damage by inhibiting the NLRP3 inflammasome (Fan et al., 2017)

Estrogen mutagenicity has also been demonstrated in transfected Big Blue rat2 embyronic cells 26 and Big Blue rats treated with 4-OHE 2 18

Derived data supporting the findings of this study are available from the corresponding author [KI] on request