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These effects can be partially reversed by restoring GSH levels, suggesting that GSH may contribute to cell death-associated responses in a context-dependent manner 212

Liver-metabolized medications deplete heme iron, reducing oxygen and nutrients to other organs

This pathway is essential for generating methyl groups required for methylation reactions, including DNA and protein methylation

Decreased in vivo glutamate/GABA ratio correlates with the social behavior deficit in a mouse model of autism spectrum disorder

Alternatively, P53 enhances the sensitivity of cells to ferroptosis by enhancing the expression of spermidine/spermine N1-acetyltransferase 1 (SAT1) and glutaminase 2 (GLS2) and inhibiting cystine uptake [101,102,103]

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