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Antagonistic crosstalk between NF-kappaB and SIRT1 in the regulation of inflammation and metabolic disorders

GSK3, Glycogen synthase kinase-3-beta

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Notably, the -mangostin-loaded formulation resulted in a greater extent of protein corona formation, likely due to changes in nanoparticle physicochemical properties, which in turn increased RAB5A and CD36 adsorption and significantly improved brain distribution and microglial uptake

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