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The synaptic changes Dihexa induces take days to fully develop and persist weeks after the initiating stimulus

attenuates 6-hydroxydopamine-induced ferroptosis in zebrafish and dopaminergic neurons

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While this research has revealed highly conserved physiological pathways (e.g., the ipRGC-SCN-melatonin axis), significant limitations exist: (1) Species differences: Human reproductive endocrine regulation is more complex and more sensitive to psychosocial factors