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Exhibiting 2- to 10-fold greater affinity for the androgen receptor (AR) relative to testosterone, DHT induces AR phosphorylation, nuclear translocation, and dimerization, thereby activating a transcriptional cascade that governs prostatic cellular homeostasis

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Extensive evidences have highlighted the interaction between mitochondrial metabolic dysfunction, mtDNA damage, mitochondrial dynamics disorders, mitophagy dysregulation, and oxidative stress, while targeting oxidative stress represents a promising strategy for combating mitochondria diseases

In contrast to the lack of brain entry of dopamine in vivo [68], our results with the targeted dopamine-nanoformulation using the BBB model combined with midbrain organoids indicate that the nanoformulation may help dopamine to reach the brain tissue after BBB penetration

Lien E, Ingalls RR

Davis, James F