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Inhibition or down-regulation of GDH expression leads to a reduction in -KG production, which in turn affects the normal physiological activity of the tumour in a manner that reduces energy supply

The safest routemedical supervision

10.1186/s12964-022-00976-3 114 YanJ.RuanP.ZhangZ.GeY.GaoJ.TanH.et al (2022)

doi: 10.1271/bbb.59.236

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Whether the acute meal terminating effects of bupropion documented in animal studies could be translated into long-term weight loss efficacy in humans was addressed by three clinical trials with overweight and obese adults (55, 56, 57) using different treatment doses (100 to 400 mg/d) and duration (up to 24 weeks)