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Macrophages As the body's initial line of defense in the innate immune response, macrophages are crucial for controlling host inflammation and preserving tissue homeostasis [68]

doi: 10.1038/s12276-018-0126-x 87

The progression of NAFLD into NASH has been described in the previous sections by the multiple hit hypothesis, in which the first hits of lipid accumulation and insulin resistance are exacerbated by inflammation, leading to further hepatic injury