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These achiral compounds have demonstrated an affinity for the NMDA receptor, for example perzinfotel (EAA-090)

Given the potential role of PUFAs in slowing the progression of SS, there has been growing interest in whether PUFAs could serve as an effective treatment for pSS patients (Table 3)

Neuropathic pain often disrupts sleep, creating a vicious cycle where poor sleep impairs healing while nerve damage disrupts sleep

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Elevated serum levels of the copper-dependent proteins semicarbazide-sensitive amine oxidase (SSAO) and CP in obese individuals were linked to increased copper levels, driven by upregulated Ctr1 and ATP7A expression in adipose tissue[92]

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