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[24] in 2021, following clinical evaluation of the association between myocardial fructose and sorbitol levels and indicators of cardiac dysfunction in diabetic patients, reported that myocardial sorbitol and fructose levels were significantly elevated in patients with T2DM

Furthermore, melatonin plays an important regulatory role in the ubiquitin-proteasome pathway, responsible for controlling protein degradation

Heart, liver, kidney and brain tissues were rapidly removed and clamped frozen at liquid N 2 temperature and stored at80 C

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References Alanazi MDS, et al

PEM is also thought to be linked to insufficient ATP levels due to a lack of available adenosine, which delays the rapid replenishment of ATP stores post-exercise and may contribute to prolonged recovery times observed in these patients following physical exertion (Lengert and Drossel, 2015)