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Disclosures: Alejandra Villamil: Novartis: Advisor, Ziad Younes: Intercept: Grant/Research Support, intercept: Consultant, intercept: Speaking and Teaching, Madrigal: Speaking and Teaching, Madrigal: Consultant, Madrigal: Grant/Research Support, cymabay: Grant/Research Support, cymabay: Consultant, ipsen: Grant/Research Support, Inventiva: Grant/Research Support, Poxel: Grant/Research Support, Altimmune: Grant/Research Support, NST: Grant/Research Support, NGM Bio: Grant/Research Support, 89Bio: Grant/Research Support, Helio: Grant/Research Support, Exact Sciences: Grant/Research Support, Corcept: Grant/Research Support, Galectin: Grant/Research Support, AstraZeneca: Grant/Research Support, Christopher Bowlus: Calliditas: Grant/Research Support, ChemoMab: Grant/Research Support, ChemoMab: Consultant, COUR Phamaceuticals: Grant/Research Support, Cymabay: Grant/Research Support, Cymabay: Consultant, Cymabay: Consultant, Gilead: Grant/Research Support, GSK Pharmaceuticals: Grant/Research Support, GSK Pharmaceuticals: Consultant, Hanmi: Grant/Research Support, Intercept: Grant/Research Support, Invea Therapeutics: Consultant, Ipsen: Grant/Research Support, Ipsen: Consultant, Mirum: Grant/Research Support, NGM Bio: Consultant, Novartis: Grant/Research Support, Novo Nordisk: Grant/Research Support, Pliant Therapeutics: Grant/Research Support, Pliant Therapeutics: Consultant, Viking Therapeutics: Grant/Research Support, Zydus Therapeutics: Grant/Research Support, John Vierling: Nothing to Disclose, Adam Vasura: Nothing to Disclose, Andrea Galli: Nothing to Disclose, Mordechai Rabinovitz: Nothing to Disclose, Frederik Nevens: Nothing to Disclose, Susheela Carroll: CymaBay Therapeutics: Employee, Calithera Biosciences: Employee, Ke Yang: Nothing to Disclose, Daria Crittenden: Nothing to Disclose, Charles McWherter: Nothing to Disclose, Eric Lawitz: Nothing to Disclose 701 ENDURANCE EXERCISE PROMOTES FAVORABLE GUT MICROBIOME COMPOSITION DURING HYPERAMMONEMIA Annette Bellar 1 Nasser Sangwan 1 Avinash Kumar 2 Muaz Alsabbagh Alchirazi 1 Pugazhendhi Kannan 1 Amy Attaway 1 Saurabh Mishra 1 Nicole Welch 1 Srinivasan Dasarathy 1 , 1 Cleveland Clinic, 2 All India Institute of Medical Sciences Background: Endurance exercise (EE) promotes a favorable gut microbiome (GMB) that includes generation of short chain fatty acid (SCFA)

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MiR-26a reduces inflammatory responses via inhibition of PGE2 production by targeting COX-2

Results: HCC cells, PLC/PRF/5, and Huh7 showed a marked increase of HIF1a protein with no significant change in the growth curve through 96 hours of culture in hypoxia

Determination and quantification of -glutamyl-valyl-glycine in commercial fish sauces

(2013) 8:e72365