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Loop E, K999 and R1000 are disordered in apo-NNT and R925 flips into an outward-facing orientation, opening the site to the solvent

et al., Genome Res 11, 1262-1268 (2001)

Maintaining an adequate GSH redox status and 25-hydroxy-vitamin D levels will have the potential to reduce oxidative stress, enhance immunity and diminish the adverse clinical consequences of COVID-19 especially in African American communities having glucose-6-phosphate dehydrogenase (G6PD) deficiency, enzyme necessary to prevent GSH exhaustion and depletion (6, 213, 310)