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Another study showed that in JHU-083-treated cancer cell allograft models, an increase in nutrient levels and oxygen and a decrease in the acidity of the TME resulted in T-cell-mediated tumor suppression 145 , whereas another study demonstrated the effects of JHU-083 on myeloid-derived suppressor cells (MDSCs) and TAMs 150

Adequately powered studies that will investigate the potential toxicity of Zn provision in premature neonates, given the trends towards higher dosing supplementation, are urgently needed

Zarzycki, P

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Other microbial metabolites, including succinate and propionate, also contribute to IEC growth, differentiation, and colonic energy metabolism (78)