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This includes patients with acute muscle strains, tendon irritation, ligament sprains, plantar fascia irritation, Achilles tendinopathy, patellar tendinopathy, rotator cuff irritation, tennis elbow, golfers elbow, or localized joint-adjacent soft-tissue pain

TIGAR is functionally similar to the diphosphatase domain of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/FBPase-2) in regulating glycolysis, ROS level and cell apoptosis (Bensaad et al., 2006)