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They are also observed in patients with sporadic PD, typically manifesting as late-onset PD closely resembling idiopathic PD in terms of clinical features and response to levodopa (Tolosa et al

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This increases inflammatory cytokines and is linked to depression.[ref] Iron build-up: An excess of iron can cause an increase in oxidative stress.[ref] Research shows that iron accumulation in the brain can cause neuropsychiatric disorders.[ref] Genetic connection to high iron: The body tightly regulates iron levels and usually only absorbs the right amount from foods

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