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B-Vitamins B1 (Thiamine) facilitates the metabolism of carbohydrates

1 2 "Cobalamin coenzyme forms are not likely to be superior to cyano- and hydroxyl-cobalamin in prevention or treatment of cobalamin deficiency"

Hospital-Grade IV Folic Acid Supplement for Rapid Correction of Folate Deficiency and Nutritional Support

My TSH and T4 have never been that far out of range but with the proper testing I found Hashimotos, which explained my constant fatigue and irregular periods (they can be anywhere from 14 days to 50+ and last 2-3 days or up to 10, and be very heavy or very light, truly irregular in all manner of ways!) Oh and folate needs testing too

Compare that to vitamins taken orally, with an average absorption rate of 10%

Your body is responding to the new signaling, but fat mobilization takes time to produce measurable changes