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Sequence alignment and structural comparison with an AlphaFold3-predicted hPAT1 model reveal both common and distinct features (Supplementary Fig

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The metabolites showing significant differences in Tbx1 +/ versus WT were MMA, which was twofold higher in Tbx1 +/ brains compared with WT brains (Fig 1A and B), and lactic acid (LA) (Fig 1A)

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