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Erectile Dysfunction: Causes and Symptoms Erectile dysfunction (ED) is the inability to achieve or maintain an erection sufficient for satisfactory sexual performance

Disease Management and Clinical Outcomes , 1, 136-141

Ruetten H, Zabel U, Linz W, Schmidt HH

Cellular mechanisms of Decreased Response Desensitization Downregulation Tachyphylaxis Tolerance Desensitization Desensitization refers to a reduced response to an agonist drug due to over activation of a receptor (high doses, prolonged exposure to agonist)

In one double-blind trial comparing GHK-Cu vs Matrixyl 3000, effects reduced wrinkles by 31.6% and improved skin firmness

Most protocols last 4-8 weeks followed by rest periods