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Epidemiology CD is one of the most common autoimmune disorders, with a reported prevalence of 0.51% of the general population (Table 1), with the exception of areas showing low frequency of CD-predisposing genes and low gluten consumption (e.g., sub-Saharan Africa and Japan) [7,8,9,10,11,12,13]

To test whether the special localization of ORF3a was important for its function in autophagy, different truncated ORF3a proteins were constructed and tested for their function in autophagy (Fig

Collectively, dysregulated l-Arg metabolism is the underlying cause of NO deficiencies, oxidative stress, and vascular aging

At present, the commonly used analgesic drugs in clinical practice are opioid analgesics and non-steroidal anti-inflammatory drugs, which often lead to dependence and addiction

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The above two mechanisms of glutamate-mediated toxicity can act cooperatively on PC12 cell death (Ma et al., 2012), while other investigators support that cell death on PC12 is exclusively due to NMDARs over activation (Penugonda et al., 2006