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This suggests DSIP functions as a normalizing agent rather than a universal sedative

Cortisol responses may vary depending on fasting duration, circadian rhythm, stress levels, sleep quality, and population characteristics, yet these variables are often underreported [45, 46]

Joshi SR, Ramachandran A, Chadha M, et al

In these five studies, venlafaxine hydrochloride extended-release capsules were statistically significantly more effective than placebo on change from baseline to endpoint on the Liebowitz Social Anxiety Scale (LSAS) total score