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5K), while OGT knockdown decreased KGA O-GlcNAcylation (Fig

1), intracellular supplementation with -EC is expected to increase GSH levels [11,12,13], thereby maintaining and enhancing the antioxidative functions of GSH

10.1016/j.scitotenv.2020.139373 37 ZhuH

rather, MAPKs appear to regulate the NRF2 signalling pathway mainly through indirect mechanisms [210]

View Article Li W, Chen C, Drelich A, Martinez DR, Gralinski LE, Sun Z, Schfer A, Kulkarni SS, Liu X, Leist SR, Zhelev DV, Zhang L, Kim YJ, Peterson EC, Conard A, Mellors JW, Tseng CK, Falzarano D, Baric RS, Dimitrov DS

In the early 1970s, glutathione (GSH) depletion was reported during mouse hepatocyte necrosis, and the addition of cysteine or GSH was observed to inhibit such cell death (6)