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Its mechanisms include the induction of OS and modulation of signaling pathways, which may also be relevant in neuropathic pain management (Lee et al., 2021)

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This is consistent with IGF-1's insulin-like activity at the IGF-1 receptor and at insulin receptors at higher concentrations

The NRI indicated that 6.95% (95 CI 2.22-11.7%) of participants were correctly recategorized when AST was added to the model, with p value 0.0042