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Some of these, including many neuropsychiatric drugs (e.g., SSRIs, SNRIs, amitriptyline & other TCAs, trazodone or nefazodone, gabapentinoids, (ar)modafinil, and Abilify), along with dihydropyridines (a subset of calcium channel blockers), fludrocortisone, midodrine, and cognitive behavioral therapy (CBT), all had over 20% of patients responding negatively

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37 Mitochondrial aconitase is highly sensitive to oxidative inactivation by superoxide radicals that are produced in close proximity by the electron transport chain (ETC)