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The amplified ATAC-seq library was purified with ATAC DNA Clean Beads and eluted with 30 l ddH 2 O

The mechanisms promoting endothelial dysfunction in the systemic and/or pulmonary circulation of COPD patients are different and include systemic inflammation, alteration of adhesion and pro-inflammatory molecules, oxidative stress, cellular senescence, and apoptosis

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Landgren S, Simms JA, Hyytia P, Engel JA, Bartlett SE, Jerlhag E

The NF-B is a key regulator of inflammation