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Reaction components were 25 M Cp1B or mutants, 5 mM ()- t -ES, 2.5 mM l-Ile, 10 mM ATP and 10 mM MgCl 2

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Fat accumulation in the visceral adipose tissue and liver has been shown to increase the secretion of proinflammatory cytokines, such as tumor necrosis factor (TNF)-, interleukin (IL)-1, IL-6, and leptin, leading to metabolic tissue inflammation and insulin resistance in obese individuals 3,4,5

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