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While weight loss is often linked to a negative impact on PD severity [181], another study suggests that PD progression is faster in patients with metabolic syndrome [182]

This section explores key microbiota-targeted approaches, from engineered bacteria to dietary interventions, focusing on their potential to therapeutically harness the microbiota-BA-immune axis in oncology, a field actively exploring microbial strategies to enhance cancer immunotherapy ( 3.2.1 Engineered microbes and microbial enzymes for precision BA immunomodulation Synthetic biology enables the engineering of bacteria or the targeting of specific microbial enzymes for precise BA modulation and subsequent immune programming

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Combined IL-15/IL-15Ralpha immunotherapy maximizes IL-15 activity in vivo