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Berberine: botanical occurrence, traditional uses, extraction methods, and relevance in cardiovascular, metabolic, hepatic, and renal disorders

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As mentioned above, erastin or sorafenib treatment can activate Nrf2 via the P62-keap1 pathway, enabling the activation of a series of target genes capable of eliciting detoxification and antioxidation response, which contributes to ferroptosis resistance [7]

Similarly, the expression and requirement of cytosolic and mitochondrial isoforms of aspartate and alanine aminotransferases are tissue- and tumour- specific

These age-related changes impair mucosal integrity and nutrient sensing, fostering a proinflammatory gut environment that can accelerate systemic aging processes