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Published pathway literature can supply background for controlled laboratory research, but it should not be converted into claims about a product

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This is legal and common, but it does mean these medications are being used outside their originally approved indications

NatureMDPI Long term human safety, pharmacokinetics, optimal dose, systemic exposure and oncologic risk signals are undefined (absence of evidence, not evidence of safety)

Data were extracted into a standardized table capturing Study design, Sample size and population, Intervention or exposure (e.g., antioxidant agent, mitochondrial marker), Outcomes (e.g., pain, fatigue, oxidative markers), Key findings relevant to the PICO questions above