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This alteration-coordinated metabolic rewiring profoundly influences macrophage gene expression, leading to unbalanced M1/M2 polarization [16,17,18,19], which determines the progression of diseases such as osteoarthritis (OA) [20], acute lung injury (ALI) [21], myocardial infarction (MI) [22], diabetic wounds [23, 24], atherosclerosis [25], and inflammatory bowel disease (IBD) [26]

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Acute cholangitis manifestations range from mild to life threatening