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the published research on the LR3 analog specifically is primarily in (a) mechanistic and pharmacokinetic studies in animals and isolated tissues, (b) cell culture applications (it is widely used as a serum-free supplement for stem cell and cell-line maintenance), and (c) analytical/anti-doping methodology (LR3 is on the World Anti-Doping Agency prohibited list)

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For example, protein arginine methyltransferase 1 (PRMT1) has been reported to function as a suppressor of ferroptosis by increasing the level of asymmetrically dimethylated histone H4 on Arg 3 (H4R3me2a) to downregulate the expression of ACSL1 and then further decrease the lipid peroxidation[208]

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