foxo4-dri vs gdf-11 induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53-serine 15 phosphorylation Structural basis for potency differences

Structural basis for potency differences between GDF8 and GDF11 BMC Biology Springer Nature Link Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age Related Cardiac Hypertrophy ScienceDirect FOXO4 DRI improves spermatogenesis in aged mice through reducing senescence associated secretory phenotype secretion from Leydig cells ScienceDirect Peptide inhibitors targeting FOXO4 p53 interactions and inducing senescent cancer cell specific apoptosis bioRxiv Growth differentiation factor 11 downregulates steroidogenic acute regulatory protein expression through ALK5 mediated SMAD3 signaling pathway in human granulosa lutein cells Reproductive Biology and Endocrinology Springer Nature Link GDF11 and aging biology controversies resolved and pending PMC

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