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In PD models, downregulated Bcl-xL expression impairs the resistance of dopaminergic neurons to mitochondrial damage, whereas exogenous upregulation of Bcl-xL markedly alleviates neuronal apoptosis [38, 39]

However, several rounds of whole-genome duplication in teleosts species (Glasauer and Neuhauss, 2014) have resulted in the presence of several paralogous genes, some of which may have resulted in divergent functions

Figure 2 3.2 Geographical variations The prevalence and incidence of PD vary across countries and regions, influenced by demographic structure, industrialization, access to healthcare, and awareness levels

Zou J, Zhang F, Zhang S, Pollack SF, Elsabahy M, Fan J, et al

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In addition, the authors validated the genome predictions with experimental data from sixteen human gut microorganisms, published elsewhere, showing that 88% of the predictions matched 34