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Results We observed that PC-12 cells treated with high-dose corticosterone at 400 M had decreased cell viability, reduced endogenous antioxidant enzyme activities, disrupted mitochondrial function, and increased oxidative stress and apoptosis

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The fasting duration and the time intervals between metformin gavage and subsequent procedures on the IPGTT day, as well as on the FDG injection measurement day, were the same as in the previous metformin experiment